INDUSTRY COMPONENT

Connection Clamp

A sterile connection clamp for secure, leak-proof interfaces in pharmaceutical and bioprocessing tanks.

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Component Specifications

Definition
A precision-engineered mechanical clamp designed to create and maintain sterile, hermetic connections between sterile product tanks and transfer lines or processing equipment in pharmaceutical, biotechnology, and aseptic manufacturing environments. It ensures contamination-free fluid transfer while withstanding sterilization cycles (SIP/CIP) and maintaining structural integrity under operational pressures.
Working Principle
Operates through a cam-locking or quick-connect mechanism that applies uniform circumferential pressure to seal gaskets or diaphragms between flanged connections, creating a sterile barrier. The clamp maintains constant sealing force through spring-loaded or over-center locking designs, preventing microbial ingress and maintaining aseptic conditions during product transfer.
Materials
316L stainless steel (ASTM A240/A276), electropolished to Ra ≤ 0.8 μm; PTFE or silicone gaskets (USP Class VI compliant); optional coatings: PTFE or ceramic for enhanced chemical resistance.
Technical Parameters
  • Leak Rate <1×10⁻⁹ mbar·L/s (helium leak test)
  • Size Range 1/2" to 4" (DN15 to DN100)
  • Sterilization Autoclavable (121°C, 30 min), SIP compatible
  • Surface Finish Electropolished, Ra ≤ 0.8 μm
  • Connection Type Tri-clamp (Sanitary Clamp)
  • Pressure Rating 10 bar (145 psi) at 20°C
  • Temperature Range -20°C to 150°C
Standards
ISO 2852, ASME BPE, DIN 32676, FDA 21 CFR Part 211

Industry Taxonomies & Aliases

Commonly used trade names and technical identifiers for Connection Clamp.

sterile connection clamp pharmaceutical tank clamp aseptic clamp tri-clamp fitting sanitary clamp bioprocessing clamp FDA compliant clamp Connection Clamp Connection Clamp in Machinery and Equipment Manufacturing

Parent Products

This component is used in the following industrial products

Sterile Product Tank Interface

Interface component connecting the sterile product tank to the aseptic filling machine's filling system

View Product Details

Engineering Analysis

Risks & Mitigation
  • Gasket failure leading to contamination
  • Improper installation causing leaks
  • Material incompatibility with process fluids
  • Fatigue failure from repeated sterilization cycles
FMEA Triads
Trigger: Gasket degradation from repeated sterilization
Failure: Loss of sterile seal, microbial contamination
Mitigation: Implement preventive maintenance schedule for gasket replacement; use dual-gasket designs with leak detection ports
Trigger: Incorrect clamp torque during installation
Failure: Uneven sealing pressure, potential leak paths
Mitigation: Use calibrated torque tools; implement installation training and verification procedures
Trigger: Corrosion from aggressive cleaning chemicals
Failure: Material degradation, particle generation
Mitigation: Specify 316L stainless steel with electropolishing; validate cleaning chemical compatibility

Industrial Ecosystem

Compatible With

Interchangeable Parts

Compliance & Inspection

Tolerance
±0.1 mm on critical dimensions; surface roughness Ra ≤ 0.8 μm
Test Method
Helium leak testing per ASTM E499; pressure testing per ASME BPE; material certification per ASTM A240/A276; cleanability testing per ASTM E3218

Procurement Evaluation Criteria

Not customer reviews or live demand data. These dimensions support RFQ preparation and supplier evaluation.

Technical documentation
4/5
Manufacturing capability
4/5
Inspection readiness
5/5
Supplier transparency
3/5

These scores are example evaluation dimensions, not real customer ratings, country-specific buyer feedback, or live inquiry activity.

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Frequently Asked Questions

What sterilization methods are compatible with this connection clamp?

The clamp is compatible with steam-in-place (SIP) up to 150°C, autoclaving at 121°C for 30 minutes, and chemical sterilization using validated agents like hydrogen peroxide or peracetic acid.

How does the clamp maintain a sterile seal during pressure fluctuations?

It uses a spring-loaded or over-center locking mechanism that maintains constant sealing force, compensating for thermal expansion and pressure variations while preventing gasket creep or relaxation.

What materials are used for gaskets in sterile applications?

PTFE (Teflon) or platinum-cured silicone gaskets that are USP Class VI compliant, non-shedding, and resistant to cleaning agents and sterilization cycles.

Can I contact factories directly?

Yes, each factory profile provides direct contact information.

Data Basis

CNFX manufacturer profiles, technical classification, publicly available product information, and ongoing plausibility checks.

Preliminary Technical Classification
This page supports structured research, RFQ preparation, and supplier evaluation. It does not replace buyer-led supplier qualification, standards review, or technical approval.

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Connection Cable/Interface Connection End